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In this issue of Neurologic Clinics, guest editor Dr. Carrie M. Hersh brings her considerable expertise to the topic of Multiple Sclerosis. Top experts in the field discuss diagnosis and pathophysiology concepts, treatment, special populations in MS, and contemporary issues related to MS. Contains 16 relevant, practice-oriented topics including recent advances in diagnostic, prognostic, and disease monitoring biomarkers in MS; the growing problem of MS misdiagnosis; highly effective therapy versus escalation approaches in early MS; clinical considerations in the diagnosis, management, and treatment of MS in Black and Latinx populations; women's health and pregnancy in MS; the era of COVID-19 in MS care; and more. Provides in-depth clinical reviews on multiple sclerosis, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.