The Leydig Cell in Health and Disease


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Nearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. The Leydig Cell in Health and Disease presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications. All aspects of Leydig cell biology, development, regulation, and physiology are explored in thirty-one expertly written chapters. The Leydig Cell in Health and Disease explores topics of great interest to the private sector, including the possible application of steroidogenesis discoveries to androgen synthesis or suppressing Leydig cell function as a key mechnanism in the development of a male contraceptive. This in-depth volume is an invaluable resource for information on the science and application of Leydig cell biology and function. TOC:From the contents Historical.- A History of Leydig Cell Research.- Cell Biology.- Structural and Histological Analysis of Leydig Cell Steroidogenic Function.- Fetal Leydig Cells: Origin, Regulation and Steroidogenesis..- Regulation Of Leydig Cells During Pubertal Development.- The Human Leydig Cell: Functional Morphology and Developmental History.- Dynamics of Leydig Cell Regeneration after EDS: A Model for Postnatal Leydig Cell Development.- Aging and the Decline of Androgen Production.- Steroidogenesis.- Regulation of Leydig Cell Cholesterol Metabolism.- The Role of StAR in Leydig Cell Steroidogenesis.- Steroidogenic Enzymes in Leydig Cells.- Development of Leydig Cell Steroidogenesis.- Peripheral Testosterone Metabolism.- Leydig Cell Aromatase: From Gene To Physiology.- The Role of Estrogen Sulfotransferase (SULT1E1) in Leydig Cells.- Endocrinology of Leydig Cells in Nonmammalian Vertebrates.- Regulation.- The Luteinizing Hormone Receptor.- Insights into Leydig Cell Function from Mice with Genetically Modified Gonadotropin Action.- Growth Factors in Leydig Cell Function.- The biology of Insulin-like peptide 3 (INSL3) in Leydig cells.- Neuronal Signaling Molecules and Leydig Cells.- Regulation of Leydig Cell Function as it pertains to the Inflammatory Response..- Activins And Leydig Cell Development, Differentiation And Disease.- Nuclear Transcription Factors as Master Regulators of Gene Expression Controlling Leydig Cell Development and Physiology.- Androgen Receptor in Leydig Cell Function and Development.- Physiology and Applied Aspects.- Fluid Exchange and Transport of Hydrophilic Factors in the Testis.- Immortalized Leydig Cell Lines as Models for Studying Leydig Cell Physiology.- Induction of Leydig Cell Tumors by Xenobiotics.- Environmental Factors that Disrupt Leydig Cell Steroidogenesis.- The Leydig Cell as a Target for Hormonal Contraception.- Clinical Evaluation of Leydig Cell Function.


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